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Denver Broncos 21–17 Philadelphia Eagles

Denver's quarterback found an 11-yard scoring throw and JK Dobbins contributed another ground touchdown in the fourth quarter as the Denver Broncos erased a 14-point deficit to deliver the Eagles their initial defeat of the season. The Broncos batted down the Eagles quarterback's final pass on the game's concluding play to send the Super Bowl champions to just their second loss in their previous 22 outings. Denver (3-2) caught a huge break in their comeback when the Philadelphia had a late fourth-down conversion nullified on a formation infraction whistled against running back Saquon Barkley.

Houston Texans 44–10 Baltimore Ravens

CJ Stroud passed for 244 passing yards and four scoring throws, and the Texans (two wins and three losses) cruised to a 44-10 win over an injury-ravaged Ravens squad, matching both the biggest away victory in Texans' history and the worst home defeat in Baltimore's annals. Baltimore (one win and four losses) were without star signal-caller Jackson, and that was far from their sole issue. Key defenders Kyle Hamilton, Roquan Smith and Marlon Humphrey all missed the game, and the Baltimore already were depleted on that side of the ball because of a cervical issue that ended Nnamdi Madubuike's campaign. The Ravens were also without All-Pro fullback Patrick Ricard and offensive lineman Stanley.

Colts Rout Raiders in One-Sided Affair

Indianapolis' running back ran for three rushing scores and a two-pointer, and Daniel Jones threw two touchdown passes as the Colts overwhelmed the Las Vegas Raiders. This decisive advantage was Indianapolis' biggest since the 2013 season. The quarterback finished 20 passes out of 29 attempts for 212 passing yards and moved to four wins and one loss as a starter this season, surpassing his total wins over the previous two years with the New York Giants. Taylor rushed 17 attempts for 66 rushing yards and caught three receptions for 20 yards. Indianapolis converted multiple takeaways into touchdowns. Las Vegas fell to 4-1.

Dallas Cowboys 37-22 New York Jets

Dallas' quarterback threw four touchdown passes, leading the Dallas Cowboys to an easy victory over the Jets. Dallas put points on the board on two long marches in the second quarter, despite missing key linemen on the blocking unit. Javonte Williams ran for 135 rushing yards and a score and also hauled in a receiving touchdown. Dallas, now two wins, two losses, and a tie, bounced back from a 40-40 tie against Green Bay last week. The Jets are still without a victory at 0-5 in their new coach's inaugural year as the leader.

Vikings Edge Browns in London Thriller

Minnesota wideout Jordan Addison caught a 12-yard touchdown pass from Carson Wentz with under half a minute remaining to secure the Vikings victory over the Browns at London's Tottenham Hotspur Stadium. This methodical march gave the Vikings (3-2) a crucial victory on their historic international road trip, which began with a narrow defeat to the Steelers in Dublin last Sunday. This also marred Dillon Gabriel's first NFL start, as the Cleveland first-year player positioned his squad (one win and four losses) in position to win by passing for two scores. Fellow rookie Quinshon Judkins rushed for 110 yards on 23 carries. The quarterback shook off a shoulder injury that temporarily forced him out and led two touchdown marches in the second half.

Miami Dolphins 24-27 Carolina Panthers

Bryce Young threw for two scores and Rico Dowdle rushed for 206 rushing yards and a score as the Panthers came back against the Dolphins in Charlotte. Young's quick throw to the first-year receiver with under two minutes to play gave the Panthers (two wins and three losses) the lead for good as they equaled the largest comeback to win a game in team history by overcoming a 17-point hole. Young had a horrific first quarter, but he ended up 19 completions on 30 attempts for 198 yards with an interception. Dowdle, replacing the sidelined starter, did his damage on the run on 23 attempts, coming up four yards shy of the team's all-time rushing mark. The Dolphins' Tua Tagovailoa completed 27 of 36 for 256 passing yards with three touchdowns and Jaylen Waddle accumulated 110 yards through the air on six receptions and scored a touchdown, but the Miami (one win and four losses) dropped to 0-3 in road games.

New York Giants 14–26 New Orleans Saints

Spencer Rattler passed for a long touchdown to Rashid Shaheed, defensive back Howden scooped up a loose ball 86 yards for a touchdown, and the Saints beat the turnover-prone New York Giants for the Saints' first victory under first-year head coach Moore. Rattler secured his maiden win in 11 professional starts, passing for 225 passing yards without any mistakes. New York's first-year signal-caller Jaxson Dart, who won his first career start last week, passed for 202 passing yards and two touchdowns, but also committed errors on three occasions. The Giants gave up possession on five separate plays in all, with none worse than when the defender forced a fumble from ball carrier Skattebo, leading to Howden's TD. Each squad are 1-4.